APOE genotype alters glial activation and loss of synaptic markers in mice

The E4 allele of the Apolipoprotein E (APOE) gene is the strongest genetic risk factor for late-onset Alzheimer's disease (AD), and affects clinical outcomes of chronic and acute brain damages. The mechanisms by which apoE affect diverse diseases and disorders may involve modulation of the glia...

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Bibliographic Details
Main Authors: Zhu, Yuangui, Nwabuisi-Heath, Evelyn, Dumanis, Sonya B., Tai, Leon, Yu, Chunjiang, Rebeck, G. William, Jo LaDu, Mary
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3276698/
https://ncbi.nlm.nih.gov/pubmed/22228589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.22289
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