Caffeic Acid Phenethyl Ester and Its Amide Analogue Are Potent Inhibitors of Leukotriene Biosynthesis in Human Polymorphonuclear Leukocytes

BACKGROUND: 5-lipoxygenase (5-LO) catalyses the transformation of arachidonic acid (AA) into leukotrienes (LTs), which are important lipid mediators of inflammation. LTs have been directly implicated in inflammatory diseases like asthma, atherosclerosis and rheumatoid arthritis; therefore inhibition...

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Detaylı Bibliyografya
Asıl Yazarlar: Boudreau, Luc H., Maillet, Jacques, LeBlanc, Luc M., Jean-François, Jacques, Touaibia, Mohamed, Flamand, Nicolas, Surette, Marc E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2012
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3276500/
https://ncbi.nlm.nih.gov/pubmed/22347509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031833
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