Caffeic Acid Phenethyl Ester and Its Amide Analogue Are Potent Inhibitors of Leukotriene Biosynthesis in Human Polymorphonuclear Leukocytes

BACKGROUND: 5-lipoxygenase (5-LO) catalyses the transformation of arachidonic acid (AA) into leukotrienes (LTs), which are important lipid mediators of inflammation. LTs have been directly implicated in inflammatory diseases like asthma, atherosclerosis and rheumatoid arthritis; therefore inhibition...

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Detalhes bibliográficos
Main Authors: Boudreau, Luc H., Maillet, Jacques, LeBlanc, Luc M., Jean-François, Jacques, Touaibia, Mohamed, Flamand, Nicolas, Surette, Marc E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3276500/
https://ncbi.nlm.nih.gov/pubmed/22347509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031833
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