Caffeic Acid Phenethyl Ester and Its Amide Analogue Are Potent Inhibitors of Leukotriene Biosynthesis in Human Polymorphonuclear Leukocytes

BACKGROUND: 5-lipoxygenase (5-LO) catalyses the transformation of arachidonic acid (AA) into leukotrienes (LTs), which are important lipid mediators of inflammation. LTs have been directly implicated in inflammatory diseases like asthma, atherosclerosis and rheumatoid arthritis; therefore inhibition...

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Autors principals: Boudreau, Luc H., Maillet, Jacques, LeBlanc, Luc M., Jean-François, Jacques, Touaibia, Mohamed, Flamand, Nicolas, Surette, Marc E.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3276500/
https://ncbi.nlm.nih.gov/pubmed/22347509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031833
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