Clicked Cinnamic/Caffeic Esters and Amides as Radical Scavengers and 5-Lipoxygenase Inhibitors

5-Lipoxygenase (5-LO) is the key enzyme responsible for the conversion of arachidonic acid to leukotrienes, a class of lipid mediators implicated in inflammatory disorders. In this paper, we describe the design, synthesis, and preliminary activity studies of novel clicked caffeic esters and amides a...

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Detalhes bibliográficos
Main Authors: Doiron, Jérémie A., Métayer, Benoît, Richard, Ryan R., Desjardins, Dany, Boudreau, Luc H., Levesque, Natalie A., Jean-François, Jacques, Poirier, Samuel J., Surette, Marc E., Touaibia, Mohamed
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207410/
https://ncbi.nlm.nih.gov/pubmed/25383225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/931756
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