AICAR Prevents Heat Induced Sudden Death in RyR1 Mutant Mice Independent of AMPK Activation

Mice with a knock-in mutation (Y524S) in the type I ryanodine receptor (RyR1) die when exposed to short periods of temperature elevation (≥ 37 °C). We demonstrate that treatment with 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) prevents heat-induced sudden death in Y524S mice. The AICAR pro...

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Detalhes bibliográficos
Main Authors: Lanner, Johanna T., Georgiou, Dimitra K., Dagnino-Acosta, Adan, Ainbinder, Alina, Cheng, Qing, Joshi, Aditya D., Chen, Zanwen, Yarotskyy, Viktor, Oakes, Joshua M., Lee, Chang Seok, Monroe, Tanner O., Santillan, Arturo, Dong, Keke, Goodyear, Laurie, Ismailov, Iskander I., Rodney, George G., Dirksen, Robert T., Hamilton, Susan L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3274651/
https://ncbi.nlm.nih.gov/pubmed/22231556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2598
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