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Purification, crystallization and preliminary X-ray crystallographic studies of the Mycobacterium tuberculosis DNA gyrase CTD

Mycobacterium tuberculosis DNA gyrase, a nanomachine involved in regulation of DNA topology, is the only type II topoisomerase present in this organism and hence is the sole target of fluoroquinolone in the treatment of tuberculosis. The C-terminal domain (CTD) of the DNA gyrase A subunit possesses...

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Main Authors: Darmon, Amélie, Piton, Jérémie, Roué, Mélanie, Petrella, Stéphanie, Aubry, Alexandra, Mayer, Claudine
Format: Artigo
Jezik:Inglês
Izdano: International Union of Crystallography 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3274397/
https://ncbi.nlm.nih.gov/pubmed/22297993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309111051888
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