Staphylococcus aureus α-Hemolysin Mediates Virulence in a Murine Model of Severe Pneumonia Through Activation of the NLRP3 Inflammasome

Staphylococcus aureus is a dangerous pathogen that can cause necrotizing infections characterized by massive inflammatory responses and tissue destruction. Staphylococcal α-hemolysin is an essential virulence factor in severe S. aureus pneumonia. It activates the nucleotide-binding domain and leucin...

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Autores principales: Kebaier, Chahnaz, Chamberland, Robin R., Allen, Irving C., Gao, Xi, Broglie, Peter M., Hall, Joshua D., Jania, Corey, Doerschuk, Claire M., Tilley, Stephen L., Duncan, Joseph A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2012
Materias:
Major Articles and Brief Reports
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3274379/
https://ncbi.nlm.nih.gov/pubmed/22279123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jir846
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