The roles of FGF and MAP kinase signaling in the segregation of the epiblast and hypoblast cell lineages in bovine and human embryos

At the blastocyst stage of mammalian pre-implantation development, three distinct cell lineages have formed: trophectoderm, hypoblast (primitive endoderm) and epiblast. The inability to derive embryonic stem (ES) cell lines in a variety of species suggests divergence between species in the cell sign...

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Main Authors: Kuijk, Ewart W., van Tol, Leni T. A., Van de Velde, Hilde, Wubbolts, Richard, Welling, Maaike, Geijsen, Niels, Roelen, Bernard A. J.
Format: Artigo
Jezik:Inglês
Izdano: Company of Biologists 2012
Teme:
Development and Stem Cells
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3274353/
https://ncbi.nlm.nih.gov/pubmed/22278923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.071688
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