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Specific Epiblast Loss and Hypoblast Impairment in Cattle Embryos Sensitized to Survival Signalling by Ubiquitous Overexpression of the Proapoptotic Gene BAD

Early embryonic lethality is common, particularly in dairy cattle. We made cattle embryos more sensitive to environmental stressors by raising the threshold of embryo survival signaling required to overcome the deleterious effects of overexpressing the proapoptotic protein BAD. Two primary fibroblas...

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Bibliografiske detaljer
Main Authors: van Leeuwen, Jessica, Berg, Debra K., Smith, Craig S., Wells, David N., Pfeffer, Peter L.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4013130/
https://ncbi.nlm.nih.gov/pubmed/24806443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0096843
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