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Specific Epiblast Loss and Hypoblast Impairment in Cattle Embryos Sensitized to Survival Signalling by Ubiquitous Overexpression of the Proapoptotic Gene BAD

Early embryonic lethality is common, particularly in dairy cattle. We made cattle embryos more sensitive to environmental stressors by raising the threshold of embryo survival signaling required to overcome the deleterious effects of overexpressing the proapoptotic protein BAD. Two primary fibroblas...

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Hlavní autoři: van Leeuwen, Jessica, Berg, Debra K., Smith, Craig S., Wells, David N., Pfeffer, Peter L.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4013130/
https://ncbi.nlm.nih.gov/pubmed/24806443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0096843
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