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The differential response to Fgf signalling in cells internalized at different times influences lineage segregation in preimplantation mouse embryos

Lineage specification in the preimplantation mouse embryo is a regulative process. Thus, it has been difficult to ascertain whether segregation of the inner-cell-mass (ICM) into precursors of the pluripotent epiblast (EPI) and the differentiating primitive endoderm (PE) is random or influenced by de...

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Autori principali: Samantha A. Morris, Sarah J. L. Graham, Agnieszka Jedrusik, Magdalena Zernicka-Goetz
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Royal Society 2013-01-01
Serie:Open Biology
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Accesso online:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.130104
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