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The differential response to Fgf signalling in cells internalized at different times influences lineage segregation in preimplantation mouse embryos

Lineage specification in the preimplantation mouse embryo is a regulative process. Thus, it has been difficult to ascertain whether segregation of the inner-cell-mass (ICM) into precursors of the pluripotent epiblast (EPI) and the differentiating primitive endoderm (PE) is random or influenced by de...

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Autors principals: Morris, Samantha A., Graham, Sarah J. L., Jedrusik, Agnieszka, Zernicka-Goetz, Magdalena
Format: Artigo
Idioma:Inglês
Publicat: The Royal Society 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843820/
https://ncbi.nlm.nih.gov/pubmed/24258274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.130104
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