Homology-directed Fanconi anemia pathway crosslink repair is dependent on DNA replication

Homologous recombination (also termed homology-directed repair, HDR) is a major pathway for the repair of DNA interstrand crosslinks (ICLs) in mammalian cells. Cells from Fanconi anemia (FA) patients are characterized by extreme ICL sensitivity, but their reported defect in HDR is mild. Here, we exa...

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Bibliografiske detaljer
Main Authors: Nakanishi, Koji, Cavallo, Francesca, Perrouault, Loïc, Giovannangeli, Carine, Moynahan, Mary Ellen, Barchi, Marco, Brunet, Erika, Jasin, Maria
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3273992/
https://ncbi.nlm.nih.gov/pubmed/21423196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2029
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