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Homology-directed Fanconi anemia pathway crosslink repair is dependent on DNA replication
Homologous recombination (also termed homology-directed repair, HDR) is a major pathway for the repair of DNA interstrand crosslinks (ICLs) in mammalian cells. Cells from Fanconi anemia (FA) patients are characterized by extreme ICL sensitivity, but their reported defect in HDR is mild. Here, we exa...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3273992/ https://ncbi.nlm.nih.gov/pubmed/21423196 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2029 |
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