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Enhanced Nitric Oxide Production during Lead (Pb(2+)) Exposure Recovers Protein Expression but not Presynaptic Localization of Synaptic Proteins in Developing Hippocampal Neurons

We have previously reported that lead (Pb(2+)) exposure results in both presynaptic and postsynaptic changes in developing neurons as a result of inhibition of the N-methyl-D-aspartate receptor (NMDAR). NMDAR inhibition by Pb(2+) during synaptogenesis disrupts downstream trans-synaptic signaling of...

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Detalhes bibliográficos
Main Authors: Neal, April P., Stansfield, Kirstie H., Guilarte, Tomás R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3273628/
https://ncbi.nlm.nih.gov/pubmed/22265330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2011.12.037
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