Lead Exposure during Synaptogenesis Alters Vesicular Proteins and Impairs Vesicular Release: Potential Role of NMDA Receptor–Dependent BDNF Signaling

Lead (Pb(2+)) exposure is known to affect presynaptic neurotransmitter release in both in vivo and cell culture models. However, the precise mechanism by which Pb(2+) impairs neurotransmitter release remains unknown. In the current study, we show that Pb(2+) exposure during synaptogenesis in culture...

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Detalhes bibliográficos
Main Authors: Neal, April P., Stansfield, Kirstie H., Worley, Paul F., Thompson, Richard E., Guilarte, Tomás R.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
Neurotoxicology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2886862/
https://ncbi.nlm.nih.gov/pubmed/20375082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfq111
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