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Dysregulation of BDNF-TrkB Signaling in Developing Hippocampal Neurons by Pb(2+): Implications for an Environmental Basis of Neurodevelopmental Disorders

Dysregulation of synaptic development and function has been implicated in the pathophysiology of neurodegenerative disorders and mental disease. A neurotrophin that has an important function in neuronal and synaptic development is brain-derived neurotrophic factor (BDNF). In this communication, we e...

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Hlavní autoři: Stansfield, Kirstie H., Pilsner, J. Richard, Lu, Quan, Wright, Robert O., Guilarte, Tomás R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3327871/
https://ncbi.nlm.nih.gov/pubmed/22345308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfs090
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