Cancer risks for the relatives of colorectal cancer cases with a methylated MLH1 promoter region: data from the Colorectal Cancer Family Registry

Methylation of the MLH1 gene promoter region is an underlying cause of colorectal cancer (CRC) with high microsatellite instability (MSI-H) diagnosed in persons without a germline mutation in a mismatch repair (MMR) gene (non-Lynch Syndrome CRC). It is unclear whether relatives of CRC cases with MLH...

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Autori principali: Levine, A. Joan, Win, Aung Ko, Buchanan, Daniel D., Jenkins, Mark A., Baron, John A., Young, Joanne P., Long, Tiffany I., Weisenberger, Daniel J., Laird, Peter W., McCall, Rebecca L., Duggan, David J., Haile, Robert W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3273599/
https://ncbi.nlm.nih.gov/pubmed/22144422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-11-0419
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