Genetic Variability in the MTHFR gene and colorectal cancer risk using the Colorectal Cancer Family Registry

BACKGROUND: The MTHFR C677T TT genotype is associated with a 15%–18% reduction in colorectal cancer (CRC) risk but it is not clear if other variants of the gene are associated with CRC risk. METHODS: We used a tagSNP approach to comprehensively evaluate associations between variation in the MTHFR ge...

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Detalhes bibliográficos
Main Authors: Levine, A. Joan, Figueiredo, Jane C., Lee, Won, Poynter, Jenny N., Conti, David, Duggan, David J, Campbell, Peter T., Newcomb, Polly, Martinez, Maria Elena, Hopper, John L., Le Marchand, Loic, Baron, John A., Limburg, Paul J., Ulrich, Cornelia M, Haile, Robert W
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805460/
https://ncbi.nlm.nih.gov/pubmed/20056627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-09-0727
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