Clinicopathological risk factor distributions for MLH1 promoter region methylation in CIMP positive tumors

BACKGROUND: The CpG Island Methylator Phenotype (CIMP) is a major molecular pathway in colorectal cancer (CRC). Approximately 25% to 60% of CIMP tumors are microsatellite unstable (MSI-H) due to DNA hypermethylation of the MLH1 gene promoter. Our aim was to determine if the distributions of clinicop...

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Detalhes bibliográficos
Publicado no:Cancer Epidemiol Biomarkers Prev
Main Authors: Levine, A. Joan, Phipps, Amanda I., Baron, John A., Buchanan, Daniel D., Ahnen, Dennis J., Cohen, Stacey A., Lindor, Noralane M., Newcomb, Polly A., Rosty, Christophe, Haile, Robert W., Laird, Peter W., Weisenberger, Daniel J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4713308/
https://ncbi.nlm.nih.gov/pubmed/26512054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-15-0935
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