Equilibrium binding of carcinogens and antitumor antibiotics to DNA: site selectivity, cooperativity, allosterism.

The equilibrium binding of the carcinogens N-hydroxy-N-acetyl-2-amino-fluorene (HAAF) and 4-nitroquinoline-1-oxide (NQO) to phi X174RF DNA have been studied by phase partition techniques. Both molecules bind in a cooperative manner with only a few carcinogen molecules binding to each phi X174RF DNA...

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Main Authors: Winkle, S A, Krugh, T R
Format: Artigo
Sprog:Inglês
Udgivet: 1981
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC327340/
https://ncbi.nlm.nih.gov/pubmed/6456451
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