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Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1
The ubiquitin (Ub)–proteasome system plays a pivotal role in the regulation of p53 protein stability and activity. p53 is ubiquitinated and destabilized by MDM2 and several other Ub E3s, whereas it is deubiquitinated and stabilized by Ub-specific protease (USP)7 and USP10. Here we show that the ovar...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3273389/ https://ncbi.nlm.nih.gov/pubmed/22124327 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.434 |
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