NuRD-mediated deacetylation of H3K27 facilitates recruitment of Polycomb Repressive Complex 2 to direct gene repression

Pluripotent cells possess the ability to differentiate into any cell type. Commitment to differentiate into specific lineages requires strict control of gene expression to coordinate the downregulation of lineage inappropriate genes while enabling the expression of lineage-specific genes. The nucleo...

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Hlavní autoři: Reynolds, Nicola, Salmon-Divon, Mali, Dvinge, Heidi, Hynes-Allen, Antony, Balasooriya, Gayan, Leaford, Donna, Behrens, Axel, Bertone, Paul, Hendrich, Brian
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3273378/
https://ncbi.nlm.nih.gov/pubmed/22139358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.431
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