Differential oestrogen receptor binding is associated with clinical outcome in breast cancer

Oestrogen receptor-α (ER) is the defining and driving transcription factor in the majority of breast cancers and its target genes dictate cell growth and endocrine response, yet genomic understanding of ER function has been restricted to model systems(1-3). We now map genome-wide ER binding events,...

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Main Authors: Ross-Innes, Caryn S., Stark, Rory, Teschendorff, Andrew E., Holmes, Kelly A., Ali, H. Raza, Dunning, Mark J., Brown, Gordon D., Gojis, Ondrej, Ellis, Ian O., Green, Andrew R., Ali, Simak, Chin, Suet-Feung, Palmieri, Carlo, Caldas, Carlos, Carroll, Jason S.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3272464/
https://ncbi.nlm.nih.gov/pubmed/22217937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10730
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