Inhibition of CaMKII Phosphorylation of RyR2 Prevents Induction of Atrial Fibrillation in FKBP12.6 knock-out Mice

RATIONALE: Abnormal calcium release from sarcoplasmic reticulum (SR) is considered an important trigger of atrial fibrillation (AF). Whereas increased CaMKII activity has been proposed to contribute to SR leak and AF-induction, downstream targets of CaMKII remain controversial. OBJECTIVE: To test th...

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Autori principali: Li, Na, Wang, Tiannan, Wang, Wei, Culter, Michael J., Wang, Qiongling, Voigt, Niels, Rosenbaum, David S., Dobrev, Dobromir, Wehrens, Xander H.T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3272138/
https://ncbi.nlm.nih.gov/pubmed/22158709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.111.253229
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