H(2)O(2)-induced dilation in human coronary arterioles: Role of protein kinase G dimerization and large-conductance Ca(2+)-activated K(+) channel activation

RATIONALE: Hydrogen peroxide (H(2)O(2)) serves as a key endothelium-derived hyperpolarizing factor mediating flow-induced dilation in human coronary arterioles (HCAs). The precise mechanisms by which H(2)O(2) elicits smooth muscle hyperpolarization are not well understood. An important mode of actio...

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Autores principales: Zhang, David X., Borbouse, Lena, Gebremedhin, Debebe, Mendoza, Suelhem A., Zinkevich, Natalya S., Li, Rongshan, Gutterman, David D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3272100/
https://ncbi.nlm.nih.gov/pubmed/22158710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.111.258871
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