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Activation of endothelial TRPV4 channels mediates flow-induced dilation in human coronary arterioles: role of Ca(2+) entry and mitochondrial ROS signaling
In human coronary arterioles (HCAs) from patients with coronary artery disease, flow-induced dilation is mediated by a unique mechanism involving the release of H(2)O(2) from the mitochondria of endothelial cells (ECs). How flow activates ECs to elicit the mitochondrial release of H(2)O(2) remains u...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3353785/ https://ncbi.nlm.nih.gov/pubmed/22140047 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00717.2011 |
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