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JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease

Parkinson's disease (PD) is a neurodegenerative disorder characterized by loss of dopamine-containing neurons, but the molecular pathways underlying its pathogenesis remain uncertain. Here, we show that by eliminating c-Jun N-terminal kinases (JNKs) we can prevent neurodegeneration and improve motor...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Hunot, Stéphane, Vila, Miquel, Teismann, Peter, Davis, Roger J., Hirsch, Etienne C., Przedborski, Serge, Rakic, Pasko, Flavell, Richard A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC327205/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14704277/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0307453101
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