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JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease

Parkinson's disease (PD) is a neurodegenerative disorder characterized by loss of dopamine-containing neurons, but the molecular pathways underlying its pathogenesis remain uncertain. Here, we show that by eliminating c-Jun N-terminal kinases (JNKs) we can prevent neurodegeneration and improve...

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Detalhes bibliográficos
Main Authors: Hunot, Stéphane, Vila, Miquel, Teismann, Peter, Davis, Roger J., Hirsch, Etienne C., Przedborski, Serge, Rakic, Pasko, Flavell, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC327205/
https://ncbi.nlm.nih.gov/pubmed/14704277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0307453101
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