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Identification of Specific Tethered Inhibitors for Caspase-5
The development of highly selective small molecule inhibitors for individual caspases, a class of cysteine-dependent aspartate-specific proteases, has been challenging due to conservation of the active site. Previously we discovered an allosteric site at the dimer interface of caspases-3, -7 and -1...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3271850/ https://ncbi.nlm.nih.gov/pubmed/22014003 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1747-0285.2011.01261.x |
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