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Protein topology determines binding mechanism

Protein recognition and binding, which result in either transient or long-lived complexes, play a fundamental role in many biological functions, but sometimes also result in pathologic aggregates. We use a simplified simulation model to survey a range of systems where two highly flexible protein cha...

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Hlavní autoři: Levy, Yaakov, Wolynes, Peter G., Onuchic, José N.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2004
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC327178/
https://ncbi.nlm.nih.gov/pubmed/14694192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2534828100
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