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The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation
The MRE11/RAD50/NBS1 complex is the primary sensor rapidly recruited to DNA double-strand breaks (DSBs). MRE11 is known to be arginine methylated by PRMT1 within its glycine-arginine-rich (GAR) motif. In this study, we report a mouse knock-in allele of Mre11 that substitutes the arginines with lysin...
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| Main Authors: | , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group
2012
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3271587/ https://ncbi.nlm.nih.gov/pubmed/21826105 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2011.128 |
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