The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation

The MRE11/RAD50/NBS1 complex is the primary sensor rapidly recruited to DNA double-strand breaks (DSBs). MRE11 is known to be arginine methylated by PRMT1 within its glycine-arginine-rich (GAR) motif. In this study, we report a mouse knock-in allele of Mre11 that substitutes the arginines with lysin...

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Main Authors: Yu, Zhenbao, Vogel, Gillian, Coulombe, Yan, Dubeau, Danielle, Spehalski, Elizabeth, Hébert, Josée, Ferguson, David O, Masson, Jean Yves, Richard, Stéphane
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2012
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271587/
https://ncbi.nlm.nih.gov/pubmed/21826105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2011.128
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