MRE11–RAD50–NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repair

Monoubiquitination of the Fanconi anaemia protein FANCD2 is a key event leading to repair of interstrand cross-links. It was reported earlier that FANCD2 co-localizes with NBS1. However, the functional connection between FANCD2 and MRE11 is poorly understood. In this study, we show that inhibition o...

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Detalhes bibliográficos
Main Authors: Roques, Céline, Coulombe, Yan, Delannoy, Mathieu, Vignard, Julien, Grossi, Simona, Brodeur, Isabelle, Rodrigue, Amélie, Gautier, Jean, Stasiak, Alicja Z, Stasiak, Andrzej, Constantinou, Angelos, Masson, Jean-Yves
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735166/
https://ncbi.nlm.nih.gov/pubmed/19609304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.193
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