Increased soluble amyloid-β peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein

Amyloid-β peptide (Aβ) is central to the pathogenesis of Alzheimer's disease, and the low-density lipoprotein receptor-related protein (LRP) has been shown to alter Aβ metabolism in vitro. Here, we show that overexpression of a functional LRP minireceptor in the brain of PDAPP mice results in a...

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Main Authors: Zerbinatti, Celina V., Wozniak, David F., Cirrito, John, Cam, Judy A., Osaka, Hiroshi, Bales, Kelly R., Zhuo, Min, Paul, Steven M., Holtzman, David M., Bu, Guojun
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC327153/
https://ncbi.nlm.nih.gov/pubmed/14732699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0305803101
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