Amyloid Precursor Protein Regulates Brain Apolipoprotein E and Cholesterol Metabolism through Lipoprotein Receptor LRP1

Mutations in the amyloid precursor protein (APP) cause early-onset Alzheimer's disease (AD), but the only genetic risk factor for late-onset AD is the ε4 allele of apolipoprotein E (apoE), a major cholesterol carrier. Using Cre-lox conditional knockout mice, we demonstrate that lipoprotein rece...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Liu, Qiang, Zerbinatti, Celina V., Zhang, Juan, Hoe, Hyang-Sook, Wang, Baiping, Cole, Sarah L., Herz, Joachim, Muglia, Louis, Bu, Guojun
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2007
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2045076/
https://ncbi.nlm.nih.gov/pubmed/17920016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2007.08.008
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