Amyloid Precursor Protein Regulates Brain Apolipoprotein E and Cholesterol Metabolism through Lipoprotein Receptor LRP1

Mutations in the amyloid precursor protein (APP) cause early-onset Alzheimer's disease (AD), but the only genetic risk factor for late-onset AD is the ε4 allele of apolipoprotein E (apoE), a major cholesterol carrier. Using Cre-lox conditional knockout mice, we demonstrate that lipoprotein rece...

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Detaylı Bibliyografya
Asıl Yazarlar: Liu, Qiang, Zerbinatti, Celina V., Zhang, Juan, Hoe, Hyang-Sook, Wang, Baiping, Cole, Sarah L., Herz, Joachim, Muglia, Louis, Bu, Guojun
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2007
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2045076/
https://ncbi.nlm.nih.gov/pubmed/17920016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2007.08.008
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