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Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease

Apolipoprotein E (APOE) genotype is the major genetic risk factor for Alzheimer disease (AD); the ε4 allele increases risk and the ε2 allele is protective. In the central nervous system (CNS), apoE is produced by glial cells, is present in high-density-like lipoproteins, interacts with several recep...

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Autors principals: Holtzman, David M., Herz, Joachim, Bu, Guojun
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3282491/
https://ncbi.nlm.nih.gov/pubmed/22393530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a006312
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