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Overcoming CML acquired resistance by specific inhibition of Aurora A kinase in the KCL-22 cell model

Serine/threonine kinase Aurora A is essential for regulating mammalian cell division and is overexpressed in many types of human cancer. However, the role of Aurora A in chemoresistance of chronic myelogenous leukemia (CML) is not well understood. Using the KCL-22 cell culture model we have recently...

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Bibliografiske detaljer
Main Authors: Yuan, Hongfeng, Wang, Zhiqiang, Zhang, Hao, Roth, Mendel, Bhatia, Ravi, Chen, Wen Yong
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271265/
https://ncbi.nlm.nih.gov/pubmed/22116466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgr278
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