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The evolution of transmembrane helix kinks and the structural diversity of G protein-coupled receptors

One of the hallmarks of membrane protein structure is the high frequency of transmembrane helix kinks, which commonly occur at proline residues. Because the proline side chain usually precludes normal helix geometry, it is reasonable to expect that proline residues generate these kinks. We observe,...

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Autors principals: Yohannan, Sarah, Faham, Salem, Yang, Duan, Whitelegge, Julian P., Bowie, James U.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC327124/
https://ncbi.nlm.nih.gov/pubmed/14732697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0306077101
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