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The evolution of transmembrane helix kinks and the structural diversity of G protein-coupled receptors

One of the hallmarks of membrane protein structure is the high frequency of transmembrane helix kinks, which commonly occur at proline residues. Because the proline side chain usually precludes normal helix geometry, it is reasonable to expect that proline residues generate these kinks. We observe,...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Yohannan, Sarah, Faham, Salem, Yang, Duan, Whitelegge, Julian P., Bowie, James U.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC327124/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14732697/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0306077101
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