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CCN3 suppresses mitogenic signalling and reinstates growth control mechanisms in Chronic Myeloid Leukaemia

CCN3, a tumour suppressor gene, is down-regulated as a result of BCR-ABL tyrosine kinase activity in Chronic Myeloid Leukaemia (CML). We have established a stable CCN3 expression model in the human K562 CML cell line and have further validated the role for CCN3 in the leukaemogenic process. K562 cel...

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Detalhes bibliográficos
Main Authors: McCallum, Lynn, Lu, Wanhua, Price, Susan, Lazar, Noureddine, Perbal, Bernard, Irvine, Alexandra E.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Netherlands 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271200/
https://ncbi.nlm.nih.gov/pubmed/21773872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12079-011-0142-2
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