Toll-like receptor activation suppresses endoplasmic reticulum stress-induced CHOP and translation inhibition through activation of eIF2B

Activation of toll-like receptors (TLRs) induces the endoplasmic reticulum (ER) Unfolded Protein Response (UPR) to accommodate essential protein translation(1,2). However, despite increased p-eIF2α, a TLR-TRIF-dependent pathway assures that the cells avoid CHOP induction, apoptosis, and translationa...

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Hlavní autoři: Woo, Connie W., Kutzler, Lydia, Kimball, Scot R., Tabas, Ira
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271190/
https://ncbi.nlm.nih.gov/pubmed/22231169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2408
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