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ONCOGENE MUTATION PROFILING OF PEDIATRIC SOLID TUMORS REVEALS SIGNIFICANT SUBSETS OF EMBRYONAL RHABDOMYOSARCOMA AND NEUROBLASTOMA WITH MUTATED GENES IN GROWTH SIGNALING PATHWAYS

Compared to the numerous broad screens for oncogene mutations in adult cancers, very few have been performed in pediatric solid tumors. To identify novel mutations and potential therapeutic targets in pediatric cancers, we performed a high-throughput Sequenom-based analysis in large sets of several...

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Autors principals: Shukla, Neerav, Ameur, Nabahet, Yilmaz, Ismail, Nafa, Khedoudja, Lau, Chyau-Yueh, Marchetti, Angela, Borsu, Laetitia, Barr, Frederic G., Ladanyi, Marc
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271129/
https://ncbi.nlm.nih.gov/pubmed/22142829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-2056
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