Accumulation of CCR4(+) CTLA-4(hi) FOXP3(+)CD25(hi) Regulatory T Cells in Colon Adenocarcinomas Correlate to Reduced Activation of Conventional T Cells

BACKGROUND: Colorectal cancer usually gives rise to a specific anti-tumor immune response, but for unknown reasons the resulting immunity is not able to clear the tumor. Recruitment of activated effector lymphocytes to the tumor is important for efficient anti-tumor responses, while the presence of...

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Main Authors: Svensson, Helena, Olofsson, Veronica, Lundin, Samuel, Yakkala, Chakradhar, Björck, Stellan, Börjesson, Lars, Gustavsson, Bengt, Quiding-Järbrink, Marianne
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271060/
https://ncbi.nlm.nih.gov/pubmed/22319577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030695
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