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CTLA-4 promotes Foxp3 induction and regulatory T cell accumulation in the intestinal lamina propria
Thymic induction of CD4(+)Foxp3(+) regulatory T (Treg) cells relies on CD28 costimulation and high-affinity T-cell receptor (TCR) signals, whereas Foxp3 (forkhead box P3) induction on activated peripheral CD4(+) T cells is inhibited by these signals. Accordingly, the inhibitory molecule CTLA-4 (cyto...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3574974/ https://ncbi.nlm.nih.gov/pubmed/22910217 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2012.75 |
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