RNA editing of the IQ domain in Ca(v)1.3 channels modulates their Ca(2+)-dependent inactivation

Adenosine-to-inosine RNA editing is crucial for generating molecular diversity, and serves to regulate protein function through recoding of genomic information. Here, we discover editing within Ca(V)1.3 Ca(2+) channels, renown for low-voltage Ca(2+)-influx and neuronal pacemaking. Significantly, edi...

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Detalhes bibliográficos
Main Authors: Huang, H, Tan, BZ, Shen, Y, Tao, J, Jiang, F, Sung, YY, Ng, CK, Raida, M, Köhr, G, Higuchi, M, Fatemi-Shariatpanahi, H, Harden, B, Yue, DT, Soong, TW
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271027/
https://ncbi.nlm.nih.gov/pubmed/22284185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2011.11.022
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