Structures of Ca(V)2 Ca(2+)/CaM-IQ domain complexes reveal binding modes that underlie calcium-dependent inactivation and facilitation

Calcium influx drives two opposing voltage-activated calcium channel (Ca(V)) self-modulatory processes: calcium-dependent inactivation (CDI) and calcium-dependent facilitation (CDF). Specific Ca(2+)/calmodulin (Ca(2+)/CaM) lobes produce CDI and CDF through interactions with the Ca(V)α(1) subunit IQ...

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Detalhes bibliográficos
Main Authors: Kim, Eun Young, Rumpf, Christine H., Fujiwara, Yuichiro, Cooley, Elizabeth S., Van Petegem, Filip, Minor, Daniel L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701236/
https://ncbi.nlm.nih.gov/pubmed/18940602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2008.07.010
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