Facilitation and Ca(2+)-dependent Inactivation Are Modified by Mutation of the Ca(v)1.2 Channel IQ Motif

The heart muscle responds to physiological needs with a short-term modulation of cardiac contractility. This process is determined mainly by properties of the cardiac L-type Ca(2+) channel (Ca(v)1.2), including facilitation and Ca(2+)-dependent inactivation (CDI). Both facilitation and CDI involve t...

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Autores principales: Poomvanicha, Montatip, Wegener, Jörg W., Blaich, Anne, Fischer, Stefanie, Domes, Katrin, Moosmang, Sven, Hofmann, Franz
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3143633/
https://ncbi.nlm.nih.gov/pubmed/21665954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.247841
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