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Mutation of the Calmodulin Binding Motif IQ of the L-type Ca(v)1.2 Ca(2+) Channel to EQ Induces Dilated Cardiomyopathy and Death
Cardiac excitation-contraction coupling (EC coupling) links the electrical excitation of the cell membrane to the mechanical contractile machinery of the heart. Calcium channels are major players of EC coupling and are regulated by voltage and Ca(2+)/calmodulin (CaM). CaM binds to the IQ motif locat...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3391132/ https://ncbi.nlm.nih.gov/pubmed/22589547 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.357921 |
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