Mutation of the Calmodulin Binding Motif IQ of the L-type Ca(v)1.2 Ca(2+) Channel to EQ Induces Dilated Cardiomyopathy and Death

Cardiac excitation-contraction coupling (EC coupling) links the electrical excitation of the cell membrane to the mechanical contractile machinery of the heart. Calcium channels are major players of EC coupling and are regulated by voltage and Ca(2+)/calmodulin (CaM). CaM binds to the IQ motif locat...

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Detalhes bibliográficos
Main Authors: Blaich, Anne, Pahlavan, Sara, Tian, Qinghai, Oberhofer, Martin, Poomvanicha, Montatip, Lenhardt, Peter, Domes, Katrin, Wegener, Jörg W., Moosmang, Sven, Ruppenthal, Sandra, Scholz, Anke, Lipp, Peter, Hofmann, Franz
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3391132/
https://ncbi.nlm.nih.gov/pubmed/22589547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.357921
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