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Patterns of Evolutionary Constraints in Intronic and Intergenic DNA of Drosophila

We develop methods to infer levels of evolutionary constraints in the genome by comparing rates of nucleotide substitution in noncoding DNA with rates predicted from rates of synonymous site evolution in adjacent genes or other putatively neutrally evolving sites, while accounting for differences in...

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Hlavní autoři: Halligan, Daniel L., Eyre-Walker, Adam, Andolfatto, Peter, Keightley, Peter D.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2004
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC327102/
https://ncbi.nlm.nih.gov/pubmed/14762063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.1329204
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